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[59] See also References Ugwu SO, Blanchard J, Dorr RT

The cleavage is mediated by furin peptidase at the S1/S2 site of the spike protein, and by transmembrane protease serine 2 (TMPRSS2) at the S2 site within the S2 domain, as shown in human airway cells 10 ( Figure 2 )

4.4 Traditional Chinese medicine in liver cancer treatment In Traditional Chinese Medicine (TCM), liver cancer falls under concepts such as jaundice and accumulation. In the early stages, liver cancer is often characterized by excess conditions, gradually progressing to a combination of excess and deficiency, and ultimately becoming deficiency with excess signs in advanced stages, closely related to pathological factors such as blood stasis and damp-heat toxins (173)

To address therapeutic non-response, combined biomarker prediction, multi-omic network reconstruction, and AI-driven dynamic monitoring have been employed to enable early identification of primary non-responders and patients with secondary loss of response

Clinical trials have shown tirzepatide produces greater average weight loss than semaglutide at equivalent timepoints, though individual response varies based on genetic and metabolic factors