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1D, the mRNA levels of P450 side-chain cleavage enzyme (P450scc) and 3-hydroxysteroid dehydrogenase (3-HSD) were not affected by treatment of GDF-11

Their headline weight-loss figures are similar (about 20.4% for CagriSema in REDEFINE 1 and about 20.9% for tirzepatide 15 mg in SURMOUNT-1), but those come from separate trials in different populations over different durations

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Any mention of published preclinical data, mechanisms of action, or experimental outcomes is provided exclusively for scientific context and literature review