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Fatigue, poor concentration, frequent illness, slow recovery, or changes in skin appearance are nonspecific and may have many different causes

Kumar NH, Kluever V, Barth E et al (2024) Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain

Bian, Q

Sci Rep 8 , 4506 (2018)

4.1.2 Stabilizing mitochondrial function in neurodegenerative models Loss of mitochondrial membrane potential (MMP), impaired ATP synthesis, and heightened oxidative/nitrosative stress can contribute to neuronal apoptosis and cognitive decline (Finsterer, 2012)