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Generally, the uptake of HMs from the contaminated soil by the plants will result in an overproduction of ROS, causing oxidative stress and damage to the plants

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[DOI] [PMC free article] [PubMed] [Google Scholar] Wang Q., et al

Co-treatment of 3-BP with cetuximab induces ferroptosis, autophagy, and apoptosis in xenograft nude mouse models To investigate whether FOXO3a plays a similar role in vivo as it does in vitro, we conducted immunoblotting and found that co-treatment induced depletion of pFOXO3a protein but accumulation of AMPK, pBeclin1, PUMA, and total FOXO3a proteins (Fig