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If tolerance is good and no concerning reactions occur, consider increasing to twice-daily application or moving to a 1 percent concentration

albicans hyphae in order to induce its apoptosis [97,98,99]

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These arguments demonstrate that models of the methionine cycle need to be examined in greater detail to determine if (i) GSH does indeed accumulate under vitamin B 12 deficiency, (ii) if it does, how does vitamin B 12 deficiency induced hyperhomocysteinemia affect GSH levels