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They share a common phenylbenzopyrone structure and are subdivided into various subclasses, including flavonols, flavones, flavanones, flavan-3-ols (catechins), anthocyanins, isoflavones, and others (14)

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Desirably, the genes should be silenced both at mRNA levels and protein levels, which was confirmed by densitometry, RT-PCR, and Western blot analysis

3.1 Pro-inflammatory cytokines The mechanisms and pathways underlying the production and release of pro-inflammatory factors by reactive astrocytes are intricate, encompassing diverse molecular cascades and intercellular interactions