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3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers

For intracellular cytokine staining, at least 1 million splenocytes were stimulated for 4.5 h in complete media containing Golgi Plug (2 g/ml) (BD Biosciences, San Jose, CA), PMA (50 ng/ml) (Sigma-Aldrich, St

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