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Further molecular investigations reveal that PFKFB4 phosphorylates nuclear receptor coactivator 3 (NCOA3), which then interacts with FBP1 to control the PPP, essential for sustaining the altered metabolic state in ccRCC and maintaining cellular redox homeostasis

Estey E, Cabanillas F, Rosenblum M, Kurzrock R, Bole J, Andreeff M , Keating M, Kantarjian H, Lopez-Berestein G

Cofactors can be classified into two types: inorganic ions and complex organic molecules called coenzymes

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However, translating mouse fat metabolism data to human outcomes requires substantial caution