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Description

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

However, in clinical practice, it is important to carefully evaluate and individually manage patients who require PPI therapy to avoid long-term abuse

"Finding that interesting loop later led to our understanding of the sensing mechanism," Birsoy says

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Post-infection, virus was removed and cells were selected with puromycin (lentiCRISPR-v2), blasticidin (pMXS_IRES_Blast) or by flow sorting of top 1% GFP+ cells (lentiCRISPR-v1(GFP))