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Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis

Using a cecal ligation and puncture (CLP) murine model, in vitro microglia-neuron co-cultures, data-independent acquisition (DIA) proteomics and liquid chromatography-mass spectrometry (LC-MS) metabolomics, SAE neuropathology and phenotypes were characterized

Another study found significant improvements in cognitive function, particularly memory, in people with mild cognitive impairment after supplementation