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Furthermore, a randomized controlled trial in patients with chronic hepatitis C demonstrated that combination therapy with UDCA and glycyrrhizin produced significantly greater reductions in serum aminotransferases and -glutamyl transpeptidase (-GTP) compared to glycyrrhizin alone, without affecting HCV RNA levels, indicating a hepatoprotective rather than antiviral synergy (Tsubota et al., 1999)

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Once the active binds its receptor, identical shutdown mechanisms apply