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In Phase 3 SURMOUNT trials, Retatrutide achieved unprecedented 24.2% mean weight loss at the 12mg dose over 48 weeks, with 91% of participants achieving 15% body weight reduction

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doi: 10.1371/journal.pone.0019046 22 MatalongaJGlariaEBresqueMEscandeCCarbJMKieferKet al

Studies focused on traumatic brain injury recovery and aging models have used 48-hour interval protocols effectively, suggesting this represents near the minimum frequency that maintains cumulative neuroplastic stimulus