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The absence of human data is not a regulatory oversight

Excessive Feces and Gases Limited bowel movements in both FC and IBS-C leads to an accumulation of excessive and hard feces in the gut lumen, which results in abnormal distension and contraction, causing feelings of pain and distension [17]

Granulomas are the primary structures that create a pro-inflammatory state in the host

It promotes angiogenesis at the injury site, activates fibroblasts, enhances growth hormone receptor expression in tendon cells, and modulates inflammation