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Several transition metal ions can catalyze Fenton and Fenton-like reactions to produce hydroxyl radicals (OH) and kill cancer cells in the TME

Essential oils exhibit anti-proliferative effects through various mechanisms such as depolarization of cell membrane, increase in membrane permeability, decrease in the activity of membrane-bound enzymes, cell cycle delays and induction of apoptosis 85

Springer, 2018

Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells

They account for almost 70% of the FAA content in human milk, they both drastically increase in the first 3 months of lactation and their levels have been shown to positively correlate with infant growth, suggestive of important functions in the developing neonate