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As previously stated, despite the development of inhibitors targeting targets associated with the glutamine metabolic pathway, and significant advancements in therapeutic strategies such as surgical resection, radiotherapy, targeted therapy, and immunotherapy, the metabolic plasticity of tumor cells contributes to their adaptability to glutamine limitation

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It has recently been demonstrated that a variety of B vitamins, all of which are generated by the microbiota to some extent, are essential for the immuno-regulatory activity of the gut microflora

[7, 8] However, qualitative assays cannot provide sufficient information for females