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Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2-Negative Metastatic Breast Cancer

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They have been shown to enhance the expression of the amyloid precursor protein (APP) processing enzyme beta-site APP cleaving enzyme 1 (BACE), thereby promoting A accumulation in patients with AD and various mouse models 54

Additionally, Leptin, a hormone produced by adipose [fat] cells, may also contribute to a reduction in feed intake by decreasing the obese animals appetite (Smith and Sherman 759)