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These cytokines activate and polarize autoaggressive T-cell subsets, leading to metabolic disorders and serious inflammation-related diseases following immune imbalance of T cells (6568)

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For example, pre-treatment with a small molecule inhibitor of P300 significantly reduced the level of lactylation in a mouse model of ischemic stroke, helping to maintain neuronal activity and alleviate ischemic brain injury [46]

Proc Radiol Soc N Am 323:173, 2000