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Inhibition of SPTLC2 or the use of antioxidants (e.g., SKQ1) reduces ceramide production and mitochondrial oxidative stress, thereby alleviating inflammation and brain damage [95]

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Promotion of BRD4 degradation by PDD was inhibited by the proteasome inhibitor MG132, the ubiquitin E1 inhibitor TAK243, or the NEDD8 E1 inhibitor MLN4293 but not by the lysosomal inhibitor bafilomycin A (Fig