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After a warning letter from the FDA was issued in July 2020, there was a subsequent debate on whether or not NAC should be sold as a supplement, because it had previously been approved for use as a drug in 1963

10.1152/ajpgi.90553.2008 109 WatanabeT.SugimoriS.KamedaN.MachidaH.OkazakiH.TanigawaT.et al (2008)

STING: Infection, inflammation and cancer

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In the detection of pro-inflammatory factor secretion, we also found that OGD treatment promoted the expression of pro-inflammatory factors, indicating that the inflammatory response was enhanced (Figure 3H)