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Description

Brinton RD, Swanson HM, Irwin RW

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Proper conformation restriction can be used to control the ligand conformation and make the molecule biased to the desired conformation binding with the target proteins as too many free rotation bonds of drug molecules are not conducive for binding [29, 30]

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In the present study, to assess the biological significance of activating the HGF/c-Met signaling pathway in the crosstalk between nerves and cancer cells, a cancer cell-DRG (dorsal root ganglion) coculture system was established, and cancer migration toward DRG and neurite outgrowth was measured

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Frontiers in Pharmacology, 12, 627533.

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