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The released SIM inhibits HMGCR, reducing downstream mevalonate pathway metabolites, such as IPP, resulting in GPX4 dysfunction, impaired lipid repair capacity, and LPO accumulation, ultimately inducing ferroptosis and establishing a comprehensive lipid metabolism regulatory axis

Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375

Williams' Clinical Page Education Medical School Indiana University School of Medicine 1979 Indianapolis IN Internship Cincinnati's Children's Hospital Medical Center 1980 Cincinnati OH Residency Cincinnati's Children's Hospital Medical Center 1982 Cincinnati OH Fellowship Hematology/Oncology Boston Children's Hospital/Dana-Farber Cancer Institute 1985 Boston MA Publications Long-term stability of posttranscriptional genetic silencing of BCL11A using a shmiR vector in Sickle Cell Disease

Thermo Fisher Scientific, Inc.) and incubated at room temperature for 20 min before being added to MDA-MB-436 cells, and the plate was incubated 48 h or 72 h under 5% CO2 at 37C

Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes