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280, 3438934392 10.1074/jbc.C500230200 [DOI] [PubMed] [Google Scholar] 18.Freidenberg, G.R., Henry, R.R., Klein, H.H., Reichart, D.R

Sermorelin is generally well-tolerated and does not inherently increase estrogen levels in a clinically significant way

Int J Biochem Cell Biol 55: 232-241

It is a completely separate signaling cascade from the one GHRH uses, which is precisely why combining the two produces synergistic rather than additive effects on growth hormone output