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In summary, the fact that NNMT plays a role in a number of diseases/conditions makes development of NNMT inhibitors an important path to developing therapeutics to treat various diseases/conditions

Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

This is further exacerbated by a plant-exclusive diet that is low in haem iron as well

Iron deficiency causes koilonychia (spoon-shaped nails), brittleness, pallor, and slow growth in severe cases

Mathematical modelling of the published trial data suggests that semaglutide and tirzepatide both substantially weaken this circuit, which is why they produce extended periods of weight loss before the plateau, compared with diet restriction alone