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The results demonstrate that the combination of TSDNPs and PD-L1 effectively eradicates OSCC tumors without causing adverse effects on normal tissues, representing a novel and effective strategy for OSCC treatment

Toxicity of 5-aza-2-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

Animal studies have revealed that betaine supplementation is associated with improved glycemic control, reduced circulating insulin levels, and diminished hepatic lipid deposition

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The percentage of ciliated cells continued to reduce in these cells at the later time points (124 h)