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10.1038/s41586-019-1237-9 66 MaQ.XingC.LongW.WangH

J Mol Biol 268:869885

It activates pathways such as ERK1/2 and FAK-paxillin, which are involved in cell growth and migration

It is the smallest AHA molecule and works well at exfoliating dead skin cells from the surface of the skin

The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)