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I am aware of its strengths, weaknesses, pitfalls and side effects

Wu Y, Zaiden N, Cao B (2018) The core- and pan-genomic analyses of the genus Comamonas : from environmental adaptation to potential virulence

These include smoking, military service, pesticide exposure, and heavy metals, with smoking raising the risk by about 40% ( 2.3.2 Clinical presentation and diagnostic challenges ALS can look very different from person to person in how it begins and how quickly it progresses