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These results suggest that the dMMR-associated somatic mutations accumulate in the later stage of hepatocarcinogenesis

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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice

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The molecular cascade associated with ROS subsequently triggers the increased expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), IL-1, and IL-18, fostering a vicious cycle of ROS and an inflammatory microenvironment within the liver (Fig