low glutathione in chronic fatigue syndrome The Role of Metabolism Illness Development and Its Potential Use as a Novel Therapeutic Target Signs of Glutathione Deficiency -

Wu H, Song W, Gao X, Liu N, Wang P, Chen H, Cai Z

Uppsala Universitet, Sweden

doi: 10.1016/j.neuroscience.2012.11.021 354 Halon-GolabekMBorkowskaAKaczorJJZiolkowskiWFlisDJKnapNet al

Indeed, it was demonstrated that heterodimerization of 1-cysPrx with GSH-saturated GSTP results in S -glutathionylation of the oxidized cysteine in 1-cysPrx followed by subsequent spontaneous reduction of the mixed disulfide and restoration of enzymatic activity ( GSH AND NITROSATIVE STRESS Besides protecting against ROS, GSH is implicated in counteracting RNS-mediated damage

Both AgNPs and Ag + ions can alter the three-dimensional structure of proteins, disrupt disulfide bonds, and block active binding sites, ultimately impairing bacterial proliferation and contribute to AgNP-mediated cytotoxicity (Lok et al., 2006)