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This possibility is reflected in its clinical plasma half-life, which in the first-in-human study was measured to 85104 hours when administered at a dosage of 250 mg/kg [224]

and the same clinical dose of the TNF- antibody used in rheumatoid arthritis has a definite effect on bronchial asthma, but has not been confirmed in COPD

Regarding the clinical data analysis, we identified a trend toward decreased survival rate in patients group with relatively high ENPP2 levels, although the result was not statistically significant