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*Correspondence: Yuhai Wang, [email protected] Xiong, [email protected] These authors have contributed equally to this work This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

By contrast, the di-ubiquitin chain slightly decreased along with the increase of monoubiquitin by OTUB1* (Fig