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Durek, T

The mitochondrial apoptotic pathway, characterized by altered Bcl-2-associated X protein (BAX)/ B-cell lymphoma 2 (BCL-2) ratio, CYTOCHROME C release, and CASPASE-3 activation, has been implicated in glyphosate-induced renal cell death during continuous exposure (11)

For each condition, 4 biological replicates were performed

Mechanistic analysis revealed that inhibition of the antioxidant pathway of the NRF2 signaling pathway via its specific inhibitor, ML385, significantly counteracted EAs protective effect against neuronal ferroptosis in NP rats while marginally diminishing its analgesic effect

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