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154 MAPK promotes ECM remodeling in PH The activated MAPK pathway observed in PAH regulates ECM remodeling in the pulmonary vasculature and right ventricle by promoting changes in fibroblast phenotype and enhancing the synthesis and secretion of ECM proteins

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It has been reported that HDAC activity is involved in RA synovial are significantly increased compared with normal controls and are in direct proportion to TNF- mRNA levels (301)