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Curcumin upregulates GAS5, which can reduce miR-10b and thereby reduce BDNF mRNA levels, or it may increase serotonin (5-HT) and dopamine levels and inhibit monoamine oxidase (MAO-A and MAO-B)

Long-term safety studies, however, have not been conducted (see Concerns and Cautions)

As with other calcium channel blockers, hemodynamic measurements of cardiac function at rest and during exercise (or pacing) in patients with normal ventricular function treated with amlodipine have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volume