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It is also used for heart disease, premenstrual syndrome (PMS), depression, morning sickness, Alzheimer disease, menstrual cramps, diabetes, and many other conditions, but there is no good scientific evidence to support many of these other uses

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FDA PCAC 2023 What this means practically for research dosage decisions: Doses above 1 mg/day are not supported by efficacy data and appear to produce diminishing returns

Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development

2003 Weyland, Jocko