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Furusawa, Y., Uruno, A., Yagishita, Y., Higashi, C

Effects of medicinal herb and Brazilian traditional plant extracts on in vitro mycotoxin decontamination

196 When the Wnt/-catenin pathway is activated, it can reduce lipid ROS production in gastric cancer cells, and the -catenin/TCF4 transcription complex can directly bind to the GPX4 promoter region, enhancing its expression and thereby inhibiting cell ferroptosis

However, in conditions of limited ATP production either due to the inhibition of ATP synthase or due to nutrient limitation and carbon shortage, these defense mechanisms fail and pyocyanin becomes auto-toxic to a majority of the P