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Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade

Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JS

464 In addition to morphological dystrophy, development of addiction is associated with significant decrease in expression of astrocytic glutamate transporters, reduced glutamate clearance, increased levels of glutamate and increased glutamate spillover in nucleus accumbens