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This enzyme is required to maintain a cellular redox state by sustaining a balance between reduced Glutathione and AsA pool by regenerating the reduced form of GSH [194]

12 The mitochondrial location of GSTK1-1 still leaves open the possibility of an essential role under particular stress conditions, such as adriamycin-induced nephropathy or when other more primary antioxidant defenses such as glutathione peroxidase, glutathione reductase and superoxide dismutase are depleted or overloaded, but this will need to be the subject of further investigations

Antioxidants as protection against reactive oxidative stress in inflammatory bowel disease

Cell 145 , 745757 (2011)

Glutathione can lighten skin by reducing melanin production, but the results are not permanent