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Caturano A, DAngelo M, Mormone A, Russo V, Mollica MP, Salvatore T, et al

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These effects appear to operate through several mechanisms: Nrf2 pathway activation : Hydrogen promotes Nrf2 translocation to the nucleus, stimulating genes involved in antioxidant production Oxidative burden reduction : By neutralizing hydroxyl radicals, hydrogen may prevent depletion of other antioxidants during oxidative challenges Mitochondrial preservation : Maintaining mitochondrial function supports energy production needed for antioxidant regeneration The relationship between hydrogen and non-enzymatic antioxidants appears bidirectional

Biochemical Pharmacology, 51(5), 443-451