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While many of these diseases were once localized to specific geographical regions, recent expansion of the causative agents (ticks, mosquitos, etc.) has resulted in an increased incidence of diseases in areas once considered low-risk

Mass Spectrom Rev 37(6):772792 lvarez R (2020) Non-targeted metabolomic analysis reveals serum phospholipid alterations in patients with early stages of Diabetic Foot Ulcer

10.1016/j.ymthe.2016.11.019 389 YanF.ZhaoQ.LiY.ZhengZ.KongX.ShuC.et al (2022a)

Esculin can inhibit oxidative stress in liver injury, as esculin (10-40 mg/kg) can activate the Nrf2 signaling pathway to increase HO-1 expression levels and decrease the MDA content in lipopolysaccharide (LPS)/D-galactosamine-induced acute liver injury mice (61)

Note that selenium is also important to protect the thyroid from oxidative damage especially when using iodine as a supplement