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a , Percentage of IL-2 producing cells (mean SEM) among unstimulated IFN- + mouse CD8 + T cells, or ex vivo-stimulated IFN- + mouse CD8 + T cells that were either left untreated (non-arrested), arrested in the cell cycle using RO-3306 (arrested), or released from RO-3306-induced arrest ( n =5 mice)

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The production of SAMe can be interrupted by an excess of oxidative stress, sulfhydryl metals and endogenous toxins such as ethanol exposure (Waly et al., 2004)

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Key points Sporadic late-onset cerebellar ataxia (SLOCA) is a syndrome defined by subacute or chronic, progressive ataxia occurring after the age of 40 years in individuals with no family history of ataxia