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Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

This research was supported by the Augusta University Intramural Pilots Project to X.Z

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Moreover, chemical or genetic manipulation of GSH pool stimulated mitophagy but not general ATG