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doi: 10.1038/s41598-020-77674-y

Detoxification is a team sport requiring: Hepatic conjugation (liver) Renal filtration (kidneys) Cellular debris transport (lymph) Binding and removal (GI tract) Brain glial cleanup and inhibition control (CNS) Blood transport to move contaminants to exits When one pathway slows, the whole system clogs

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10.1074/jbc.M414077200 J

In mouse models, loss of enzymes that modulate LDL oxidation increases atherosclerosis, and dietary antioxidants that reduce levels of oxLDL also inhibit atherosclerosis