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Apart from Nlrp3 inflammasome, mitogen-activated protein kinases (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) are involved in the pathogenesis of chronic inflammation ( Figure 2 MAPKs are a group of conserved serine/threonine protein kinases, including ERK, JNK, and p38

Knowing this helps your doctor decide which treatment you need

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While the repairing phase, the majority of macrophages convert into reparative M2 phenotype that acts to resist acute inflammation by secreting anti-inflammatory cytokines like IL-10 and insulin-like growth factor-1

Based on animal studies, there may be potential risks to an unborn baby from exposure to tirzepatide during pregnancy