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Abstract Objective Diabetic nephropathy is one of the most serious complications associated with long-term diabetes mellitus

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Discussion The BBB poses a significant impediment to drug delivery, with over 98% of pharmaceutical agents unable to efficiently traverse it, thereby diminishing their therapeutic efficacy in treating various neurological disorders, including neurodegenerative diseases 35

Most incretin-based drugs were also beneficial on total and LDL-cholesterol, with the greatest reduction observed with retatrutide (12.8% and 16.5%, respectively)