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Furthermore, the presence of pulmonary metabolizing enzymes, including cytochrome P450 mixed-function oxidases and flavin-containing monooxygenases, suggests that these compounds may undergo biotransformation within the lung, potentially contributing to their toxic effects 49

10.1007/s11926-021-00981-4 4 Adjei-SowahE.Recalde PhillipsS

Additionally, neuronal nitric oxide synthase (nNOS) produces nitric oxide ( NO) that can react with superoxide (O 2 ) to form peroxynitrite (ONOO ), a potent oxidant that triggers nitrosative stress and further cell damage [14,19]

Anti-Inflammatory Effects While inflammation serves an important initial role in healing, prolonged inflammation delays recovery and can contribute to chronic pain