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Molecular and cellular pathways associated with pathogenesis of Alzheimers disease Non-amyloidogenic and amyloidogenic pathways in AD A 142 and A 140 peptide monomers are produced by APP in the amyloidogenic pathway and assemble into the characteristic amyloid plaques of AD

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Analogously, NMT1-NAC could represent an early co-translational chaperone system for nascent myristoylated proteins, shielding their hydrophobic N-terminus during biosynthesis