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Competing interests The authors have declared no competing interests

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

Taken together, these effects may explain the differences in disease control rates in this trial and offer insight as to the appropriate interval between different anti-CD38 antibody therapies