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A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)

Serious side effects are extremely uncommon, but allergic reactionsincluding rash, swelling, or breathing difficultiesshould be treated as medical emergencies

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The combination of room temperature and light exposure creates synergistic degradation effects

There is a chance that peptides besides GLP-1s will eventually be demonstrated to provide health outcome benefits as seen in rodent pre-clinical models