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Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

Notably, we did not observe a change in any other fluorescent reporters that measure the activation of other cellular stress responses (supplemental figure 4a-e)

The experience of Charles River Laboratories Phase I clinic over a 10-year period from 1996 to 2005 indicates that the incidence of treatment-emergent Serious Adverse Events in Phase I studies in healthy volunteers is low