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PMCID: PMC6472203

Tschp MH, Speakman JR, Arch JRS, Auwerx J, Brning JC, Chan L, et al

However, in the context of chronic COPD, the function of M2 macrophages may be impaired, leading to an imbalance with M1 macrophages ( Modulating macrophage polarization, inhibiting pro-inflammatory signaling pathways, and promoting tissue repair mechanisms are potential approaches for attenuating inflammation, reducing tissue damage, and improving lung function in individuals with COPD